Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2087 |
AF-353
Ro-4 |
P2X Receptor | Membrane transporter/Ion channel; Neuroscience |
AF-353 (Ro-4) 是一种选择性、可口服的 P2X3/P2X2/3 受体拮抗剂,抑制人和大鼠 P2X3 的 pIC50值为 8.0,抑制人 P2X2/3 的 pIC50值为 7.3。 | |||
T3559 |
4-Oxoisotretinoin
Oxoretinoic acid,4-Oxoisotretinoin,Ro 22-6595 |
Others | Others |
4-Oxoisotretinoin (Ro 22-6595) 是主要的血液代谢物。 | |||
T12745L |
(4R)-RO5263397
|
Others | Others |
(4R)-4-(3-Fluoro-2-methylphenyl)-4,5-dihydro-2-oxazolamin 对 TRACE AMINE ASSOCIATED RECEPTOR (TAAR 1)具有活性,EC50为0.017 μM,可用来研究神经系统疾病。 | |||
T8139 |
Sulfamethoxazole sodium
新诺明钠,Ro 4-2130 sodium,磺胺甲恶唑钠 |
Others; Antibacterial; Antibiotic | Microbiology/Virology; Others |
Sulfamethoxazole sodium (Ro 4-2130 sodium) 是一种磺胺类抗菌素。它常用于各种尿道病原体的研究,与 Trimethoprim 联用,可用于尿路感染的研究。 | |||
T1517 |
Benserazide hydrochloride
Benserazide HCl,盐酸苄丝肼,Serazide,Ro 4-4602 |
Dopamine Receptor | GPCR/G Protein; Neuroscience |
Benserazide hydrochloride (Ro 4-4602) 是一种芳香族 L-氨基酸脱羧酶(AADC)的抑制剂,常用于帕金森病。 | |||
T34361 |
Ro 4-6824
AI3-50843 |
||
Ro 4-6824 is a biochemical with immunosuppressive action. | |||
T0885 |
Sulfamethoxazole
Ro 4-2130,STX 608,磺胺甲恶唑 |
Antibacterial; Antibiotic; Autophagy | Autophagy; Microbiology/Virology |
Sulfamethoxazole (STX 608) 是磺胺类抗菌素,用于细菌感染。Sulfonamides 是对氨基苯甲酸的竞争性拮抗剂。 | |||
T14489 |
Azvudine
4-氨基-1-(4-C-叠氮基-2-脱氧-2-氟-BETA-D-呋喃阿拉伯糖基)-2(1H)-嘧啶酮,FNC,RO-0622 |
HCV Protease; HBV; HIV Protease; Reverse Transcriptase | Microbiology/Virology; Proteases/Proteasome |
Azvudine (FNC) 是一种有效的核苷逆转录酶抑制剂 (NRTI),对 HIV、HBV 和 HCV 具有抗病毒活性。它抑制耐 NRTI 的病毒株,高效抑制 HIV-1和 HIV-2。 | |||
T7745 |
Diclofensine hydrochloride
4-(3,4-二氯苯)-7-甲氧基-2-甲基-1,2,3,4-四氢异喹啉盐酸盐,Ro 8-4650 hydrochloride |
Others; Dopamine Receptor | GPCR/G Protein; Neuroscience; Others |
Diclofensine hydrochloride (Ro 8-4650 hydrochloride) 是一种高效单胺再摄取抑制剂,在大鼠脑突触体中能够阻断多巴胺 (IC50=0.74 nM)、去甲肾上腺素 (IC50=2.3 nM) 和 5-羟色胺 (IC50=3.7 nM)。 | |||
T1488L |
Procarbazine free base
CB 400-497,NSC-77213,Ro 4-6467/1,Ro 4-6467,Procarbazine |
||
Procarbazine is an antineoplastic chemotherapy drug for the treatment of Hodgkin's lymphoma and certain brain cancers. The drug is metabolized and activated in the liver. It also inhibits MAO thus increasing the effects of sympathomimetics, TCAs, and tyra | |||
T19706 |
Ro 20-1724
Ro-20-1724,4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone,Ro20-1724 |
PDE | Metabolism |
Ro 20-1724 (4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone) 是 cAMP 特异性磷酸二酯酶抑制剂 b>(PDE4/PDE IV),其 Ki=1930 nM,具有神经保护作用。 | |||
T13031 |
Sulfamethoxazole-d4
Ro 4-2130 D4,磺胺甲恶唑 D4 |
Others | Others |
Sulfamethoxazole D4 is a deuterium labeled Sulfamethoxazole (Ro 4-2130). Sulfamethoxazole is a sulfonamide bacteriostatic antibiotic. | |||
T11679 |
Isavuconazole-d4
BAL-4815 D4,RO-0094815 D4,Isavuconazole D4 |
Others | Others |
Isavuconazole D4 is a deuterium labeled Isavuconazole. Isavuconazole is a triazole prodrug with antifungal activity against yeasts, molds, and dimorphic fungi. | |||
T12718 |
RG7800 hydrochloride (1449598-06-4 free base)
RO6885247 hydrochloride,RG7800 hydrochloride |
Others | Others |
RG7800 hydrochloride is an orally active modulator of SMN2 splicing. | |||
T6312 |
R547
Ro 4584820 |
Apoptosis; GSK-3; PKA; CDK | Apoptosis; Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors |
R547 (Ro 4584820) 是一种口服有效,选择性, ATP 竞争性CDK 抑制剂,对 CDK1/cyclin B、 CDK2/cyclin E 和 CDK4/cyclin D1 作用的Ki 值分别为 2 nM、3 nM、1 nM。 | |||
T28595 |
Ro-0505124
Ro0505124,Ro 0505124 |
||
Ro-0505124 is a potent, selective and ATP-competitive inhibitor of cyclin-dependent kinase 4 (CDK4). | |||
T70838 | RO27-3225 TFA | ||
RO27-3225, also known as RO273225 is a melanocortin type 4 receptor agonist with EC50 = 1 nM. It may alleviate intestinal dysfuntion and brain damage. It has been investigated for an anti-obesity medication. Ro 27-3225 shows some activity at the MC1 receptor. Ro 27-3225 reverses hemorrhagic shock, reduces multiple organ damage, and improves survival. |